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pentobarbital will decrease the level or effect of alprazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will lessen the level or effect of alosetron by impacting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unfamiliar.Contraindicated (1)pentobarbital will lessen the level or effect